Ololiuqui belongs to the LSA seeds, which means it has some qualities similar to LSD, as well in chemical structure as in results. For a long time not many others than the Indians of Mexico had knowledge about the use of ololiuhqui. In this area it was the most widely used hallucinogenic. Today you can find the seeds in almost all the villages of Oaxaca, where they serve the natives by providing help or answers to them. The seeds are used for their psychedelic purposes by the Aztec priests in order to communicate with their gods. Ololiuhqui is also used in traditional Mexican medicine as a cure for flatulence, to remedy venereal troubles, to dull pain, and to remove tumors. It's been said to work miracles, when properly propitiated.
Ololiuhqui does not produce such direct hallucinations like LSD or shrooms, the trip is comparable to the hypnotic state produced by morning glory. The Indians report powerful visions, even at lower doses. Possibly this is particularly due to cultural conditioning and the guiding of shamans.
The most essential psychoactive substance is ergine. It has been demonstrated that this produces a dreamlike trance or even a twilight sleep with vision images.
The traditional and most suitable method of preparation is to soak the finely ground or chewed seeds in half a cup of water for several hours, then consuming both the water and seeds.
The traditional dose consists of 14 to 22 seeds (R. Gordon Wasson, 'Ololiuhqui and the other hallucinogens of Mexico' in 'Homenaje a Roberto J. Weitlaner'. 1971). There have been experiments where these amounts elicited no effects among Western subjects. Eventually they ingested up to 60 - 100 seeds. Higher dosages led to nothing but vomiting and several other undesirable side-effects.
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